Human pharmacokinetics and CSF penetration of clavulanic acid
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چکیده
منابع مشابه
Pharmacokinetics and tissue penetration of ticarcillin combined with clavulanic acid.
A combination of 3 g of ticarcillin and 200 mg of clavulanic acid was administered intravenously to six healthy male volunteers, after which the concentrations of these agents in serum and blister fluid were measured. The ratio of the two drugs in serum varied from 15:1 (ticarcillin-clavulanic acid) at the time of administration to 28:1 at 30 min and 62:1 at 5 h after injection. Both agents pen...
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The pharmacokinetic properties of amoxicillin and clavulanic acid when used alone or in combination may be different and show interaction between these two agents that might decrease the absolute bioavailability of clavulanic acid. In an open, randomized, replicated Latin square under fasting condition, pharmacokinetics of new formulations of amoxicillin/clavulanic acid were compared with...
متن کاملBone penetration of amoxicillin and clavulanic acid evaluated by population pharmacokinetics and Monte Carlo simulation.
Amoxicillin (amoxicilline)-clavulanic acid has promising activity against pathogens that cause bone infections. We present the first evaluation of the bone penetration of a beta-lactam by population pharmacokinetics and pharmacodynamic profiling via Monte Carlo simulations. Twenty uninfected patients undergoing total hip replacement received a single intravenous infusion of 2,000 mg/200 mg amox...
متن کاملIntraperitoneal penetration of ticarcillin/clavulanic acid (Timentin).
Thirty-eight patients undergoing elective abdominal surgery were given 3.0 g ticarcillin plus 0.2 g clavulanic acid as a single intravenous injection at varying times prior to the operation. Sterile assay discs were placed on the peritoneal surface in order to measure peritoneal fluid levels of each agent. Simultaneous serum levels were also measured. A total of 38 serum and peritoneal samples ...
متن کاملpharmacokinetics of amoxicillin/clavulanic acid combination after oral administration of new suspension formulations in human volunteers
the pharmacokinetic properties of amoxicillin and clavulanic acid when used alone or in combination may be different and show interaction between these two agents that might decrease the absolute bioavailability of clavulanic acid. in an open, randomized, replicated latin square under fasting condition, pharmacokinetics of new formulations of amoxicillin/clavulanic acid were compared with a ref...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 1981
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/8.1.29